Agmatine is a metabolic byproduct of Arginine. It is formed within the body after L-Arginine undergoes decarboxylation. Agmatine is basically Arginine with the carboxylic acid end removed. Agmatine produces the byproducts guanidino-butyladehyde and the polyamines putruscene, spermine, and spermidine which are involved in cell growth. Agmatine is found in tissues throughout the body and is synthesized and stored astrocytes, glial cells in the brain and spinal cord, which provide structural and metabolic support to the nervous system. Agmatine acts as a neurotransmitter and neuromodulator with a vast array of actions in the body. Agmatine is an imidazoline receptor agonist. Imidazoline receptors have several functions: regulation of insulin secretion, pain modulation, and neuroprotection/neuromodulation. Clonidine, another imidazoline receptor agonist, has been noted to stimulate the release of luteinizing hormone (LH). Researchers conducted tests on agmatine and found that it can also modulate the release of LH from its interaction with hypothalamic tissues. The modulation of imidazoline receptors by agmatine has also been shown to improve insulin sensitivity. Agmatine can also drive some of the body?s natural fat burning pathways. NutraBio?s Agmatine Sulfate capsules undergo encapsulation without the use of fillers or excipients.